Uridine 5'-monophosphate synthase

Function Uridine 5’-monophosphate synthase (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an orotate phosphoribosyl transferase (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is orotidine 5’-phosphate decarboxylase (OPD) which decarboxylates OMP to form UMP. Disease Defects in UMPS result in the hereditary rare metabolic disease orotic aciduria. UMPS deficiency in Holstein cattle results in an autosomal disorder which causes early embryonic death of offspring.

spinqualitylabelsall models Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP (stick model), 2v30 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of uridine 5'-monophosphate synthase3D structures of uridine 5'-monophosphate synthase

Updated on 08-December-2016

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• Uridine 5’-monophosphate synthase OPD subunit
  • 3gdk - yOPD – yeast
    
  • 1dqw, 3gdr, 3gdm – yOPD (mutant)
    
  • 2eaw, 2jgy, 2p1f, 2qcc, 2qce - hOPD – human
• Uridine 5’-monophosphate synthase OPD subunit complex
  • 2v30, 2qcd - hOPD + UMP
    
  • 3ewy - hOPD (mutant) + UMP
    
  • 3gdl - yOPD + UMP derivative
    
  • 1dqx, 3gdt - yOPD (mutant) + UMP derivative
    
  • 2qcg, 2qch, 3bgg, 3bgj, 3bk0, 3g3d, 3g3m, 3ewz, 3ex2, 3ex3, 3ex4, 3dbp, 3l0k, 3l0n, 3mo7, 3mw7 - hOPD + UMP derivative
    
  • 3bvj - hOPD + xanthosine 5’-monophosphate
    
  • 2qcf, 2qcm, 2qcn, 3ewu, 3ewx, 3ex6 - hOPD (mutant) + UMP derivative
    
  • 3mi2, 4hib, 4hkp - hOPD + inhibitor
    
  • 3ex1 - hOPD + UMP derivative + UMP
    
  • 2qcl - yOPD (mutant) + OMP
• Uridine 5’-monophosphate synthase OPRT subunit complex
  • 2wns - hOPRT + OMP