SAGA-associated factor

SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.

spinqualitylabelsall models Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow), UB8P (grey), glycerol and Zn+2 ions (grey) (PDB entry 3mhs) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of SAGA-associated factor3D structures of SAGA-associated factor

Updated on 21-August-2016

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• SGF11
  • 2lo2 – ySGF zinc finger domain – yeast – NMR
    
  • 3kik, 3kjl – ySGF Sus1-binding domain + Sus1
    
  • 3mhh, 3m99, 4fip, 4fjc, 4fk5, 4wa6 – yUBP8 + Sus1 +SGF73 - yeast
    
  • 3mhs – yUBP8 + Sus1 +SGF73 + ubiquitin
    
• SGF29
  • 3me9, 3mea, 3met, 3meu, 3mev, 3mew, 3mp1, 3mp6 – hSGF tudor domain + histone H3 peptide – human
    
  • 3lx7, 3mp8 - hSGF tudor domain
    
• SGF73
  • 2lo3 – ySGF zinc finger domain – NMR