Adenosine kinase

Function Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. Disease AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy. Structural highlights AdK consists of a . The is formed along the edge of the β sheet in the large domain.

spinqualitylabelsall models Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of adenosine kinase3D structures of adenosine kinase

Updated on 01-December-2015

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• Adenosine kinase
  • 1lio – TgAdK – Toxoplasma gondii
    
  • 2pkf – MtAdK – Mycobacterium tuberculosis
    
  • 4n08 – TbAdK – Trypanosoma brucei
    
• Adenosine kinase binary complex
  • 1bx4 – hAdK + adenosine - human
    
  • 2i6a, 2i6b – hAdK + prodrug
    
  • 4o1l – hAdK + inhibitor
    
  • 1dgm, 1lik – TgAdK + adenosine
    
  • 2a9y – TgAdK (mutant) + dimethyladenosine
    
  • 2abs – TgAdK (mutant) + AMP-PCP
    
  • 2aa0 – TgAdK (mutant) + methylthiopurine
    
  • 2pkk, 4ube – MtAdK + fluoroadenosine
    
  • 2pkn – MtAdK + AMP-PCP
    
  • 2pkm – MtAdK + adenosine
    
  • 4o1g – MtAdK + γ-thio-ATP
    
  • 4pvv – MtAdK + inhibitor
    
  • 3loo – AdK + adenosine tetraphosphate – Anopheles gambiae
    
  • 2xtb – TbAdK + morpholine
    
• Adenosine kinase ternary complex
  • 1lii – TgAdK + adenosine + AMP-PCP
    
  • 2a9z – TgAdK (mutant) + dimethyladenosine + AMP-PCP
    
  • 1lij – TgAdK + prodrug + AMP-PCP
    
  • 2ab8 – TgAdK (mutant) + methylthiopurine + AMP-PCP
    
  • 3ubo – AdK + adenosine + ADP – Sinorhizobium meliloti
    
  • 4dc3 – AdK + adenosine + fluoroadenosine – Schistosoma masoni
    
  • 4n09 – TbAdK + adenosine + ADP