Adenosine kinase

Function

Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.^[1]

Disease

AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.

Structural highlights

AdK consists of a (PDB entry 1bx4).^[2]

. Water molecules are shown as red spheres.
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3D structures of adenosine kinase

Adenosine kinase 3D structures

Structure of human adenosine kinase complex with adenosine, Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry 1bx4)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1
↑ Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

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Michal Harel, Alexander Berchansky

[1] Park J, Gupta RS. Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci. 2008 Sep;65(18):2875-96. doi: 10.1007/s00018-008-8123-1. PMID:18560757 doi:http://dx.doi.org/10.1007/s00018-008-8123-1

[2] Mathews II, Erion MD, Ealick SE. Structure of human adenosine kinase at 1.5 A resolution. Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365 doi:10.1021/bi9815445

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