Annexin

FunctionFunction

Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. Annexin E1 (AnE1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella. In the annexin image calcium ions are shown as green balls.

Structural highlightsStructural highlights

Annexins consist of 2 domains - the C-terminal core and the N-terminal head.

3D structures of annexin3D structures of annexin

Updated on 02-November-2015

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• Annexin I
  • 2q4c, 1ycn - AnI - Arabidopsis thaliana
    
  • 1mcx, 1hm6 - pAnI - pig
    
  • 1qls - pAnI head+calgizzarrin
    
  • 1bo9 - hAnI head - human NMR
    
  • 1ain - hAnI
    
  • 4mdv, 4mdu – AnI + Ca – Schistosoma mansoni
    
• Annexin II
  • 2hyu, 2hyv - hAnII+heparin oligosaccharide
    
  • 2hyw, 1xjl - hAnII+Ca
    
  • 1w7b - hAnII
    
  • 1bt6 - hAnII head+calpactin light chain
    
  • 4hre – AnII + protein S100-A10 + helicase-like transcription factor
    
  • 4x9p – AnII – bovine
    
• Annexin III
  • 1aii, 1axn - hAnIII
    
• Annexin IV
  • 2zhi, 2zhj, rAnIV+Na - rat
    
  • 2zoc - hAnIV
    
  • 1i4a - cAnIV (mutant) - cow
    
  • 1aow, 1ann - cAnIV
    
• Annexin V
  • 2ie6, 2ie7, rAnV
    
  • 1n41, 1n42, 1n44, 2h0k, 2h0l, 2h0m, 1bc0, 1bc1, 1bc3, 1bcw, 1bcy, 1bcz - rAnV (mutant)
    
  • 1g5n - rAnV+ heparin oligosaccharide
    
  • 1a8a, 1a8b - rAnV+phospholipid analog
    
  • 2ran - rAnV+Ca
    
  • 1yii – chAnV+Ca – chicken
    
  • 1yj0 - chAnV+Zn
    
  • 1ala - ChAnV
    
  • 1hak - hAnV+K-201
    
  • 1sav - hAnV (thioproline)
    
  • 1hvd, 1hve, 1hvf, 1hvg - hAnV (mutant)
    
  • 1anw, 1avh, 1avr - hAnV
    
  • 1anx - hAnV+Ca
    
  • 2xo2 – hAnV + Ca + azidohomoalanine
    
  • 2xo3 - hAnV + Ca + homopropargylglycine
• Annexin VI
  • 1m9i - hAnVI (mutant)
    
  • 1avc - cAnVI+Ca
    
• Annexin VIII
  • 1w3w - hAnVIII
    
  • 1w45 - hAnVIII (mutant)
    
• Annexin XII
  • 1dm5 - HvAnXII (mutant) - Hydra vulgaris
    
  • 1aei - HvAnXII
    
• Annexin E1
  • 3chj – GlAnE1 – Giardia lamblia
    
  • 3chk, 3chl – GlAnE1 + cation
• Other annexins
  • 1dk5 - An24 - Capsicom annuum
    
  • 3brx - coAnGH1+Ca - cotton
    
  • 1n00 - coAnGH1