Plasmepsin

Template:STRUCTURE 3fns Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive.

3D structures of plasmepsin3D structures of plasmepsin

Updated on 02-September-2014

HAPHAP

3fns, 3qvc – PfHAP - Plasmodium falciparum
3fnt – PfHAP + pepstatin
3fnu, 3qvi – PfHAP + inhibitor

Plm IPlm I

3qrv – PfPlm I residues 117-457
3qs1 - PfPlm I residues 117-457 + inhibitor

Plm IIPlm II

1lf4 – PfPlm II
3f9q – PfPlm II (mutant)
2r9b – PfPlm II + peptide inhibitor
1w6h, 2bju, 1lf2, 1lf3, 1lee, 2igx, 2igy – PfPlm II + inhibitor
1w6i, 1xdh, 1xe5, 1xe6, 1me6, 1sme – PfPlm II + pepstatin derivative
1m43 - PfPlm II (mutant) + pepstatin derivative

ProPlm IIProPlm II

1pfz - PfProPlm II
1miq – PvProPlm II – Plasmodium vivax
1qs8 - PvPlm + pepstatin derivative

Plm IVPlm IV

2anl – Plm IV + statine derivative – Plasmodium malariae
1ls5 - PfPlm IV + pepstatin derivative