BAG protein

<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (stick model) (PDB entry 3fzf)' scene=>

The BAG family proteins (Bcl-2 associated athanogenes) perform diverse functions. They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved. BAG-1, BAG-2, BAG-4, BAG-5 or BAG family molecular chaperone regulator inhibit the chaperone function of HSC70 and have anti-apoptotic function.

3D structures of BAG family proteins3D structures of BAG family proteins

Updated on 18-November-2014

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• BAG-1
  • 1i6z – mBAG-1 BAG domain - mouse
    
  • 2lwp – mBAG-1 BAG domain - NMR
    
  • 1t7s – BAG-1 BAG domain – Caenorhabditis elegans
    
  • 4hwc – AtBAG-1 BAG domain – Arabidopsis thaliana
    
  • 1wxv – hBAG-1 BAG domain – human - NMR
    
• BAG-1 complex with HSC70
  • 3fzf – hBAG-1 BAG domain + HSC70 ATPase domain + ATP
    
  • 3fzh, 3fzk, 3fzl, 3fzm, 3ldq, 3m3z – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor
    
  • 4hwi – AtBAG-1 BAG domain + HSC70 ATPase domain
    
  • 1hx1 – BAG-1 BAG domain + HSC70 ATPase domain - bovine
    
• BAG-2
  • 3d0t – mBAG-2 BAG domain
    
• BAG-2 complex with HSC70
  • 3cqx – mBAG-2 BAG domain + HSC70 ATPase domain
    
• BAG-4
  • 1m62, 1m7k – hBAG-4 BAG domain - NMR
    
• BAG-5
  • 1ugo – mBAG-5 BAG domain - NMR
    
  • 2d9d – hBAG-5 BAG domain - NMR
    
• BAG-5 complex with HSC70
  • 3a8y – hBAG-5 BAG domain + HSC70 ATPase domain
    
• BAG-6
  • 4eew – hBAG-6 UBL domain