1m7k

Solution Structure of the SODD BAG DomainSolution Structure of the SODD BAG Domain

Structural highlights 1m7k is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function BAG4_HUMAN Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The solution structure of an N-terminally extended construct of the SODD BAG domain was determined by nuclear magnetic resonance spectroscopy. A homology model of the SODD-BAG/HSP70 complex reveals additional possible interactions that are specific for the SODD subfamily of BAG domains while the overall geometry of the complex remains the same. Relaxation rate measurements show that amino acids N358-S375 of SODD which were previously assigned to its BAG domain are not structured in our construct. The SODD BAG domain is thus indeed smaller than the homologous domain in Bag1 defining a new subfamily of BAG domains. The solution structure of the SODD BAG domain reveals additional electrostatic interactions in the HSP70 complexes of SODD subfamily BAG domains.,Brockmann C, Leitner D, Labudde D, Diehl A, Sievert V, Bussow K, Kuhne R, Oschkinat H FEBS Lett. 2004 Jan 30;558(1-3):101-6. PMID:14759524 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also BAG family proteins 3D structures

spinqualitylabelsall models 1m7k Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image