Fibroblast growth factor

Fibroblast growth factors (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF signaling is important in the pathogenesis of a variety of tumor types. FGF1 is called acidic FGF while FGF2 is called basic FGF. FGF7 is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound.

3D structures of fibroblast growth factor3D structures of fibroblast growth factor

Updated on 06-March-2014

FGF1FGF1

1fmm – FGF1 – Notophthalmus viridescens - NMR
1afc – bFGF1 + HS – bovine
1bar – bFGF1
2j3p – rFGF1 - rat
3hal – FGF1 - rabbit
2afg, 1jqz, 1rg8 – hFGF1 - human
1jt3, 1jt4, 1jt5, 1jt7, 1jtc, 1k5u, 1k5v, 1m16, 1jy0, 1nzk, 1p63, 1pzz, 1q03, 1q04, 1yto, 1z2v, 1z4s, 2aqz, 2hw9, 2hwa, 2hwm, 2hz9, 2ntd, 3b9u, 3ba4, 3ba5, 3ba7, 3bad, 3bag, 3bah, 3bao, 3baq, 3bau, 3bav, 3bb2, 2q9x, 3crg, 3crh, 3cri, 3cqa, 3fgm, 3fj8, 3fj9, 3fja, 3fjb, 3fjc, 3fjd, 3fje, 3fjf, 3fjh, 3fji, 3fjj, 3fjk, 3hom, 3o3q – hFGF1 (mutant)
1dzd, 2rq9 – hFGF1 - NMR
1dzc – hFGF1 (mutant) - NMR

FGF1 complex with small molecule

1axm, 2axm – hFGF1 + HS
3ud7, 3ud8, 3ud9, 3uda – hFGF1 + disaccharide
2uus – rFGF1 + HS
2erm – hFGF1 + HS - NMR
1rml – hFGF1 + naphthalene trisulphonate - NMR
1hkn – hFGF1 + naphthalene trisulphonate
2k8r – hFGF1 + anti-angiogenic drug - NMR
3k1x – hFGF1 + vasoprotectant drug
3jut – hFGF1 + inhibitor
2ki4, 2ki6 – hFGF1 + S100-A13

FGF1 complex with FGF receptor

1e0o – hFGF1 (mutant) + hFGFR2 (mutant) + HS
3oj2, 3ojm, 1djs – hFGF1 + hFGFR2 (mutant)
1evt – hFGF1 + hFGFR1
3ojv – hFGF1 + hFGFR1 (mutant)
1ry7 – hFGF1 + hFGFR3
3cu1 – hFGF1 + hFGFR2

FGF2FGF2

2fgf – hFGF2 precursor
1fga, 4fgf, 1bas, 1bfg, 2bfh, 1bff – hFGF2
1wvz, 2k43, 2k4a – hFGF2 - NMR
1bla, 1bld – hFGF2 (mutant) - NMR
1bfb, 1bfc – hFGF2 + heparin
1cvs – hFGF2 (mutant) + hFGFR1 (mutant)
1fq9 – hFGF2 (mutant) + hFGFR1 (mutant) + HS
1ev2 - hFGF2 (mutant) + hFGFR2
2m49 - hFGF2 (mutant) + S100-B

FGF4FGF4

1ijt – hFGF4 b-trefoil domain

FGF7FGF7

1qqk – rFGF7
1qql – rFGF7/hFGF1

FGF8FGF8

2fdb – hFGF8b + hFGFR2

FGF9FGF9

1g82, 1ihk – hFGF9

FGF10FGF10

1nun – hFGF10 + hFGFR2

FGF12FGF12

1q1u – hFGF12 (mutant)

FGF13FGF13

3hbw – hFGF13
4dck – hFGF13 + calmodulin + sodium channel subunit α

FGF19FGF19

1pwa, 2p23 – hFGF19

FGF20FGF20

3f1r – hFGF20

FGF23FGF23

2p39 – hFGF23