Adenylate kinase
Adenylate kinase (ADK) is a phosphotransferase which catalyzes the interconversion of ADP to ATP+AMP. ADK is important in cellular energy homeostasis. Dinucleotides polyphosphates like diadenosine pentaphosphate (AP5) inhibit ADK. The images at the left and at the right correspond to one representative ADK, i.e. the crystal structure of Adenylate kinase from Desulfovibrio gigas (3l0p).
3D Structures of Adenylate kinase3D Structures of Adenylate kinase
ADK unligandedADK unliganded
4ake - EcADK - Escherichia coli
3gmt - ADK - Burkholderia pseudodomallei
3cm0 - ADK - Thermus thermophilus
2rh5 - AaADK - Aquifex aeolicus
1p4s - MtADK - Mycobacterium tuberculosis
2ar7 - hADK 4 - human
1ki9 - ADK - Methanococcus thermolithotrophicus
1ak2, 2ak2 - bADK - bovine
3adk - ADK - pig
ADK mononucleotide complexADK mononucleotide complex
1ank - EcADK+AMP+AMPPNP
2cdn - MtADK+ADP
2bwj - hADK 5+AMP
1kht - ADK+AMP - Methanococcus voltae
1nks - ADK+AMP+ADP - Sulfolobus acidocaldarius
2ak3 - bADK+AMP
1dvr - yADK (mutant)+ATP analog - yeast
ADK complex with dinucletide polyphosphatesADK complex with dinucletide polyphosphates
3hpq, 3hpr, 1e4v, 1e4y - EcADK (mutant)+AP5
1ake - EcADK+AP5
3h86 - ADK+AP5 - Methanococcus maripaludis
3fb4 - ADK+Zn+AP5 - Marinibacillus marinus
3dkv, 3dl0, 1p3j - BsADK+Zn+AP5 - Bacillus subtilis
2qaj, 2oo7, 2p3s, 2ori, 2osb, 2eu8 - BsADK (mutant)+Zn+AP5
2rgx - AaADK+Zn+AP5
3be4 - ADK+AP5 - Cryptosporidium parvum
2c9y - hADK 2+bis-adenosine tetraphosphate
2bbw - hADK 4+GP5
1s3g - ADK+Zn+AP5 - Bacillus globisporus
1zak - ADK+AP5 - maize
1zip, 1zin - ADK+Zn+Mn+AP5 - Bacillus stearothermophilus
1aky, 2aky - yADK+AP5
3aky - yADK (mutant)+AP5
ADK complexes with ionsADK complexes with ions
3l0p - DgADK+Fe - Desulfovibrio gigas
3l0s - DgADK+Co
2xb4 - DgADK+Zn