2bwj

Structure of adenylate kinase 5Structure of adenylate kinase 5

Structural highlights

2bwj is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAD5_HUMAN Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Solaroli N, Panayiotou C, Johansson M, Karlsson A. Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 2009 Sep 3;583(17):2872-6. PMID:19647735 doi:10.1016/j.febslet.2009.07.047
↑ Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N. The human adenylate kinase 9 is a nucleoside mono Int J Biochem Cell Biol. 2013 May;45(5):925-31. PMID:23416111 doi:10.1016/j.biocel.2013.02.004

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OCA

[1] Solaroli N, Panayiotou C, Johansson M, Karlsson A. Identification of two active functional domains of human adenylate kinase 5. FEBS Lett. 2009 Sep 3;583(17):2872-6. PMID:19647735 doi:10.1016/j.febslet.2009.07.047

[2] Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N. The human adenylate kinase 9 is a nucleoside mono Int J Biochem Cell Biol. 2013 May;45(5):925-31. PMID:23416111 doi:10.1016/j.biocel.2013.02.004

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