Cluster of Differentiation CD38

File:3gc6a.jpg

Crystal Structure of bovine Cluster of Differentiation 38 (CD38) 3gc6

Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling. The images at the left and at the right correspond to one representative CD38, i.e. the crystal structure of bovine Cluster of Differentiation 38 (3gc6).

3D Structures of Cluster of Differentiation 383D Structures of Cluster of Differentiation 38

CD38CD38

3gc6 – bCD38 - bovine
3gh3, 3ghh – bCD38 residues 32-278
2eg9 - CD38 enzymatic domain (mutant) – mouse
2ef1 - hCD38 enzymatic domain – human
1yh3 - hCD38 enzymatic domain (mutant)
1zvm - hCD38 (mutant)

CD38+ligandCD38+ligand

3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog
3f6y – hCD38 enzymatic domain+Ca++
3dzf - hCD38 enzymatic domain+intermediate
3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex
3dzh - hCD38 enzymatic domain (mutant)+GTP
3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex
3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex
2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog
2o3t - hCD38 enzymatic domain (mutant)+cGDPR
2o3u - hCD38 enzymatic domain (mutant)+NGD
2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR
2i65 – hCD38+NAD
2i66 - hCD38 (mutant)+GDP intermediate
2i67 - hCD38 (mutant)+ADPR
2hct - hCD38 enzymatic domain (mutant)+NMN