Villin
3D Structure of Villin
The image at the top is a Human Supervillin Headpiece (2k6n)
VillinVillin
Villin (VIL) is an actin-binding protein. The images at the top and at the right correspond to one representative Villin structure, i.e. human supervillin headpiece (2k6n). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the Gelsolin superfamily which is expressed in the peripheral sensory neurons.
3D Structures of Villin3D Structures of Villin
SupervillinSupervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
VillinVillin
3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
AdvillinAdvillin
1und – hAVIL headpiece