Ragulator complex

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The ragulator complex (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it[1].

3D structures of ragulator complex

Ragulator complex 3D structures

Updated on 05-May-2025

6b9x - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + hepatitis B virus interacting protein - human

5y39, 5y3a, 6ehp, 5x6u - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5
5x6u - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5
5yk3 - hLAMTOR1 + LAMTOR2 (mutant) + LAMTOR3 + LAMTOR4 (mutant) + LAMTOR5
6ehr - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C
5x6v - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C
6wj2, 6wj3 - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C + Na-coupled neutral amino acid transporter
6ulg - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Folliculin + folliculin-interactin protein + Ras-related GTP-binding proteins A, C – Cryo EM
6nzd - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Folliculin + folliculin-interactin protein + Ras-related GTP-binding proteins A, C – Cryo EM
6wj2, 6wj3 - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + sodium-coupled neutral amino acid transporter + Ras-related GTP-binding proteins A,C + GDP – Cryo EM
6u62 - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + RAPTOR + Ras-related GTP-binding proteins A, C – Cryo EM
5vok, 5y38, 5yk5 - hLAMTOR4 + LAMTOR5

References

  1. ↑ Mu Z, Wang L, Deng W, Wang J, Wu G. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discov. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49. eCollection, 2017. PMID:29285400 doi:http://dx.doi.org/10.1038/celldisc.2017.49

Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey and cyan) + LAMTOR2 roadblock domain (green and red) + LAMTOR3 roadblock domain (pink and gold) + LAMTOR4 roadblock domain (yellow and wheat) + LAMTOR5 roadblock domain (magenta and blue) PDB code 5y39

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Michal Harel, Wayne Decatur
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