6wj3

CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP stateCryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state

Structural highlights

6wj3 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.9Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RRAGC_HUMAN Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.^[1]

References

↑ Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr , 8. PMID:20381137 doi:10.1016/j.cell.2010.02.024

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OCA

[1] Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr , 8. PMID:20381137 doi:10.1016/j.cell.2010.02.024

[1]

6wj3

CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP stateCryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state

Structural highlights

Function

See Also

References

Contents

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6wj3

CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP stateCryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state

Structural highlights

Function

See Also

References

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