RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]
Structural highlights
1fi8 is a 6 chain structure with sequence from Escherichia coli and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GRAB_RAT This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
