Mitogen-activated protein kinase 3D structures

3D Structures of Mitogen-activated protein kinase3D Structures of Mitogen-activated protein kinase

Updated on 08-September-2020

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• MAPK1 or ERK2
  • 4g6n, 4g6o, 4gsb – hMAPK1 - human
    
  • 3i5z, 3i60, 3w55, 2ojg, 2oji, 2ojj, 1wzy, 1tvo, 3sa0, 4fux, 4fuy, 4fv0, 4fv1, 4fv2, 4fv3, 4fv4, 4fv5, 4fv6, 4fv7, 4fv8, 4fv9, 4n4s, 4o6e, 4qp1, 4qp2, 4qp3, 4qp4, 4qp6, 4qp7, 4qp8, 4qp9 4qpa, 4qta, 4qte, 4xj0, 4xne, 4xoy, 4xoz, 4xp0, 4xp2, 4xp3, 4xrj, 4xrl, 4zzm, 4zzn, 4zzo, 5bue, 5bui, 5buj, 5bvd, 5bve, 5bvf, 5hd4, 5hd7, 5k4i, 5ke0, 5lcj, 5lck, 5ngu, 5nhf, 5nhh, 5nhj, 5nhl, 5nho, 5nhp, 5nhv, 5u6i, 6g8x, 6g91, 6g92, 6g93, 6g97, 6g9a, 6g9d, 6g9h, 6g9j, 6g9k, 6g9m, 6g9n, 6gdm, 6gdq, 6ge0, 6dcg, 5wp1, 6qaw, 6qaq, 6qal, 6qah, 6qag, 6qa4, 6qa3, 6qa1, 6q7t, 6q7s, 6q7k, 6nbs, 6gjd, 6gjb, 6ge0, 6gdq, 6gdm, 6g9n, 6g9m, 6g9j, 6g9k, 6g9h, 6g9d, 6g9a, 6g97, 6g93, 6g92, 6g91, 6g8x, 6g54, 6dmg, 6rq4 – hMAPK1+inhibitor - human
    
  • 2y9q – hMAPK1 + MAP kinase-interacting Ser/Thr protein kinase peptide
    
  • 3tei, 4h3p, 4nif – hMAPK1 (mutant) + ribosomal protein S6 kinase α-1
    
  • 4iz5, 4iz7, 4iza – hMAPK1 (mutant) + astrocytic phosphoprotein
    
  • 4fmq – hMAPK1 + MAPK docking peptide
    
  • 5v62, 5v61, 6slg – hMAPK1 + ERK2 peptide + inhibitor
    
  • 4h3q – hMAPK1 + MAP2K 2 peptide
    
  • 5ax3 – hMAPK1 + allosteric inhibitor peptide
    
  • 4n0s – hMAPK1 + cafeic acid
    
  • 4zxt – hMAPK1 + catechol
    
  • 5v60 – hMAPK1 + ACP
    
  • 6opg – hMAPK1 + AMPPNP
    
  • 1erk, 4s31, 5umo - rMAPK1 - rat
    
  • 1gol, 3r63, 4s2z, 4s30, 6rfp - rMAPK1 (mutant)
    
  • 2z7l, 3c9w, 3qyw, 3qyz, 4qyy, 6cpw, 6opk, 6opi, 6oph, 6fxv, 6frp, 6fr1, 6fq7, 6fn5, 6fma, 6flv, 6fle, 6fjz, 6fjb, 6fj0, 6fi6, 6fi3 - rMAPK1+inhibitor
    
  • 2gph - rMAPK1 (mutant)+HEPTP (mutant)
    
  • 3o71 - rMAPK1 + colorectal cancer peptide
    
  • 2fys - rMAPK1 + KIM peptide
    
  • 4s32 – rMAPK1 + AMPPNP
    
  • 4s33, 4s34 – rMAPK1 (mutant) + AMPPNP
    
  • 4gt3, 4gva – rMAPK1 + nucleotide
    
  • 4i5h – rMAPK1 (mutant) + inhibitor
    
  • 3o71 - rMAPK1 + colorectal cancer peptide
    
  • 3zu7, 3zuv – rMAPK1 + ankyrin repeat protein
    
  • 2y4i – raMAPK1+kinase suppressor of RAS 2 – rabbit
    
  • 3oz6 - MAPK1 - Cryptosporidium parvum
• MAPK2
  • 1kwp – hMAPK2
    
  • 3gok - hMAPK2 kinase domain
    
  • 2pzy, 2p3g, 2jbo, 2jbp – hMAPK2 kinase domain +inhibitor
    
  • 3a2c, 3kc3, 3fpm, 3fyj, 3fyk, 3r2b, 3r2y, 3r30, 3wi6 - hMAPK2 kinase domain +inhibitor
    
  • 3m2w, 3kga, 3ka0, 3m42 – hMAPK2 kinase domain (mutant)+inhibitor
    
  • 2oza, 2onl – hMAPK2+ hMAPK14
    
  • 4tyh, 6tca - hMAPK2+ hMAPK14 + inhibitor
    
  • 1nxk – hMAPK2 + staurosporine
    
  • 1ny3 – hMAPK2 + ADP
    
  • 2npt - hMAPK2 PHOX domain + hMAPK5
    
  • 2erk – rMAPK2
    
  • 3erk, 4erk – rMAPK2+inhibitor
    
• MAPK3 or ERK1
  • 2zoq – hMAPK3
    
  • 3r1n, 3she, 4qtb, 3fxw, 3fhr, 6ges – hMAPK3 kinase domain +inhibitor
    
• MAPK6
  • 2i6l – hMAPK6
    
  • 6dtl – MAPK3 residues 32-395 – Arabidopsis thaliana
    
• MAPK7 or ERK5 kinase domain

• • 4ic8 – hMAPK7
    
  • 4b99, 4zsg, 4zsj, 4zsl, 5byy, 5byz, 5o7i, 6hkn, 6hkm – hMAPK7+inhibitor
    
  • 4ic7 – hMAPK7+ MAP2K 5
    
• MAPK8
  • 3o17, 2gmx, 2g01, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum – hMAPK8 (mutant)+JIP1 peptide
    
  • 1ukh, 1uki - jMAPK8 JNK1+JIP1 peptide
    
  • 6f5e - hMAPK8 JNK1+JIP1 peptide + darpin
    
  • 5lw1 - hMAPK8 JNK1+JIP1 peptide + darpin + pepstatin
    
  • 3v3v - hMAPK8 JNK1+JIP1 peptide + quercedagetin
    
  • 3o2m - hMAPK8 (mutant)+JIP1 peptide+biaryl tetrazole
    
  • 2xrw, 2xs0 - hMAPK8 + NFAT peptide
    
  • 4ux9 – hMAPK8 + MAPKK7 peptide
    
  • 4yr8 – hMAPK8 + MKP7
    
  • 3elj, 3pze, 4awi, 4l7f, 4qtd - hMAPK8+inhibitor
    
  • 4e73, 4g1w, 4hys, 4hyu, 4izy – hMAPK8 + JIP1 +inhibitor
    
  • 2no3, 2h96 – hMAPK8 (mutant)+inhibitor
    
• MAPK9
  • 3e7o, 7cml - hMAPK9 (mutant)
    
  • 3npc – hMAPK9 (mutant)+inhibitor
    
• MAPK10
  • 3kvx, 3fv8, 2waj, 3fi2, 3fi3, 3da6, 2zdt, 2zdu, 3cgf, 3cgo, 2r9s, 2o0u, 2o2u, 2exc, 2b1p, 1pmn, 4z9l, 1pmu, 1pmv, 3oy1, 2ok1, 3ttj, 3tti, 3rtp, 3v6r, 3v6s, 4kkh, 4u79, 4whz, 4x21, 4y46, 4y5h, 3g9l, 3g90, 3g9n, 2p33, 6emh, 6ekd – hMAPK10 catalytic domain + inhibitor
    
  • 3ptg, 4h39 - hMAPK10 catalytic domain + JIP1 peptide
    
  • 4h36 – hMAPK10 catalytic domain + ATF2 peptide
    
  • 4h3b – hMAPK10 catalytic domain + SAB peptide
    
  • 4kke, 4kkg – hMAPK10 catalytic domain + AMPPNP
    
  • 6eq9 – hMAPK10 catalytic domain + ACP
    
  • 3oxi - hMAPK10 + MAPK8 interacting protein + inhibitor
    
• MAPK11
  • 3gp0 – hMAPK11+inhibitor
    
  • 3gc8, 3gc9 – hMAPK11 (mutant)+inhibitor
    
• MAPK12
  • 6una – hMAPK12 (mutant)
    
• MAPK13
  • 3coi, 4yno, 4myg – hMAPK13
    
  • 4eyj, 4eym, 5ekn, 5eko - hMAPK13 +inhibitor
    
• MAPK14
  • 3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3hvc, 3npq, 1wbo, 1r39, 2npq, 1wfc, 1cm8, 5etc, 5eti, 5uoj – hMAPK14
    
  • 2lgc – hMAPK14 – NMR
    
  • 3od6, 3ody, 3odz, 3oef, 3p4k, 2fsl, 2fsm, 2fso, 2fst, 1r3c, 4e5a, 4geo – hMAPK14 (mutant)
    
  • 3new, 3ocg, 3mvl, 3mvm, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3mpt, 3lhj, 3huc, 3itz, 3l8x, 3kf7, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3flm, 3fln, 3fsf, 3fsk, 3kq7, 3iph, 3hv4, 3hv5, 3hv6, 3hv7, 3k3i, 3hec, 3heg, 3gi3, 3hp2, 3hp5, 3hrb, 3ha8, 3gfe, 3hl7, 3hll, 3gcu, 3fc1, 3dt1, 3e92, 3e93, 3d7z, 3d83, 3ctq, 2puu, 3bx5, 3c5u, 2zaz, 2zb0, 2zb1, 2qd9, 2ewa, 2gfs, 2baj, 2bak, 2bal, 2baq, 1zyj, 1wbn, 1wbs, 1wbt, 1wbv, 1wbw, 1zz2, 1zzl, 1yqj, 1w7h, 1w82, 1w83, 1w84, 1oz1, 1ouk, 1ouy, 1m7q, 1kv1, 1kv2, 1di9, 2rg5, 2rg6, 3bv3, 3bv2, 3fmm, 3fmn, 3lfa, 3mw1, 3pg3, 3roc ,2yis, 2yiw, 2yix, 3qud, 3que, 3rin, 3s3i, 3s4q, 3u8w, 3uvp, 3uvq, 3uvr, 3zs5, 3zsg, 3zsh, 3zsi, 3zya, 4a9y, 4aa0, 4aa4, 4aa5, 4aac, 4dli, 4dlj, 4e5b, 4eh2, 4eh3, 4eh4, 4eh5, 4eh6, 4eh7, 4eh8, 4eh9, 4ehv, 4ewq, 4f9w, 4f9y, 4fa2, 4kin, 4kip, 4kiq, 4l8m, 4r3c, 4zth, 5lar, 5ml5, 5tbe, 5tco, 6anl, 5xyy, 5xyx, 5wjj, 5n68, 5n67, 5n66, 5n65, 5n64, 5n63, 5mz3, 5mty, 5mtx, 5o8v, 5o8u, 6sfo, 6sfk, 6sfj, 6sfi, 6m9l, 6m95, 6hwv, 6hwu, 6hwt, 6ohd, 6qdz, 6qe1, 6sfi, 6sfj, 6sfk, 6sfo, 6so1, 6so2, 6so4, 6sod, 6soi, 6sot, 6sou, 6sov, 6sp9, 6spl, 6zwp - hMAPK14+inhibitor
    
  • 4e6a, 4e6c, 4e8a - hMAPK14+ lipid
    
  • 3o8t, 3mpa, 3obg, 3o8u, 3o8p, 3obj, 3oc1, 3hub, 3l8s, 3hv3, 3iw5, 3iw6, 3iw7, 3iw8, 3k3j, 3gc7, 3gcp, 3gcq, 3gcs, 3gcv, 3ds6, 2i0h, 1ove, 3lfb, 3lfc, 3lfd, 3lfe, 3lff, 1bl6, 1bl7, 1bmk, 1a9u, 1ian - hMAPK14 (mutant)+inhibitor
    
  • 2y8o – hMAPK14 (mutant) + dual specificity MAP2K peptide
    
  • 4ka3, 4loo, 4lop, 4loq – hMAPK14 + docking peptide
    
  • 5eta – hMAPK14 + peptide
    
  • 3tg1 – hMAPK14 + MAPK phosphatase 5
    
  • 5etf – hMAPK14 + MAPKK 6
    
  • 2gtn, 2gtm, 3p5k, 3p78, 3p79, 3p7a, 3p7b, 3p7c, 6spl, 6sp9, 6sov, 6sou, 6sot, 6soi, 6sod, 6so4, 6so2, 6so1, 6y4t, 6y4u, 6y4v, 6y4w, 6y4x, 6y6v, 6yjc, 6yk7, 6zwr - mMAPK14+inhibitor
    
  • 2ghm, 2ghl, 1ywr, 6y7w, 6y7x, 6y7y, 6y7z, 6y80, 6y81, 6y82, 6y85, 6y8h, 6ycu, 6ycw - mMAPK14 (mutant)+inhibitor
    
  • 3py3 - mMAPK14 phosphorylated
    
  • 1yw2, 5uoj - mMAPK14 (mutant)
    
  • 1lew - mMAPK14+MEF2A
    
  • 1lez - mMAPK14+MKK3B
    
  • 5nzz – mMAPK14 + TGF
    
  • 5o90 – mMAPK14 (mutant) + TGF peptide
    
• MAPK Fus3
  • 2f9g, 2b9f – yMAPK Fus3 – yeast
    
  • 2fa2 – yMAPK Fus3 (mutant)
    
  • 2f49 - yMAPK Fus3 +STE5 peptide
    
  • 2b9h, 2b9i - yMAPK Fus3 (mutant)+MSG5 peptide
    
  • 2b9j - yMAPK Fus3 (mutant)+FAR1 peptide
    
• MAPK
  • 3rp9 – TgMAPK – Toxoplasma gondii
    
  • 6v6a – TgMAPK + AC9 peptide
    
  • 3uib – MAPK + inhibitor – Leishmania major