Cyclin-dependent kinase regulatory subunit

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Function

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in where CDK1 is in grey, pink, magenta and gold and CKS1 i in green, yellow, cyan and red. CKS1 is essential for CDK5 functioning in neuronal differentiation.[1]

Structural highlights

CKS exists as hexamer of homodimers and can bind six kinase molecules.

3D Structures of cyclin-dependent kinase regulatory subunit

Cyclin-dependent kinase regulatory subunit 3D structures


Human CKS-1 complex with phosphate (PDB code 1dks)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. Tang Y, Reed SI. The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae. Genes Dev. 1993 May;7(5):822-32. PMID:8491379

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Michal Harel, Alexander Berchansky