Transcription factor tau

Function

Transcription factor tau or TFIIIC is required for transcription of tRNA and 5S RNA genes by RNA polymerase III^[1]. TFIIIC conserved complex is involved in the mechanism controlling general genome organization^[2]. TFIIIC is a multisubunit protein which initiates transcription complex assembly on tRNA by binding to the internal box B promoter element of RNA polymerase III^[3].

Structural highlights

The structure of TFIIIC subunit SCF1 DNA-binding domain contains a winged-helix domain and displays a basic patch which is the possible DNA-binding surface^[4].

Se-Met structure of TFIIIC subunit SCF1 DNA-binding domain (PDB code 4bji)

Drag the structure with the mouse to rotate

3D structures of transcription factor tau3D structures of transcription factor tau

Updated on 18-November-2018

Domains: dimerization 1-110; histidine phosphatase 1-272; DNA-binding 186-396; N-terminal TPR array 123-566; central EWH 546-641

4bjj - fyTFIIIC subunits SFC1 + SFC7 dimerization domain - fission yeast
4bji - fyTFIIIC subunit SFC1 DNA-binding domain
2yn0 - yTFIIIC subunit SFC7 histidine phosphatase domain - yeast
5aem, 5aio - yTFIIIC subunit SFC4 N-terminal TPR array
5aim - yTFIIIC subunit SFC3 central EWH domain

ReferencesReferences

↑ Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. J Biol Chem. 2007 Jun 8;282(23):17179-89. doi: 10.1074/jbc.M611542200. Epub 2007 , Apr 4. PMID:17409385 doi:http://dx.doi.org/10.1074/jbc.M611542200
↑ Noma K, Cam HP, Maraia RJ, Grewal SI. A role for TFIIIC transcription factor complex in genome organization. Cell. 2006 Jun 2;125(5):859-72. PMID:16751097 doi:10.1016/j.cell.2006.04.028
↑ L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ. Human transcription factor IIIC box B binding subunit. Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1652-6. PMID:8127861
↑ Taylor NM, Baudin F, von Scheven G, Muller CW. RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74. Nucleic Acids Res. 2013 Aug 5. PMID:23921640 doi:10.1093/nar/gkt664

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Michal Harel, Alexander Berchansky

[1] Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. J Biol Chem. 2007 Jun 8;282(23):17179-89. doi: 10.1074/jbc.M611542200. Epub 2007 , Apr 4. PMID:17409385 doi:http://dx.doi.org/10.1074/jbc.M611542200

[2] Noma K, Cam HP, Maraia RJ, Grewal SI. A role for TFIIIC transcription factor complex in genome organization. Cell. 2006 Jun 2;125(5):859-72. PMID:16751097 doi:10.1016/j.cell.2006.04.028

[3] L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ. Human transcription factor IIIC box B binding subunit. Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1652-6. PMID:8127861

[4] Taylor NM, Baudin F, von Scheven G, Muller CW. RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74. Nucleic Acids Res. 2013 Aug 5. PMID:23921640 doi:10.1093/nar/gkt664

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