Thermolysin

Function Thermolysin (TML) is a thermostable metalloproteinase enzyme from Bacillus thermoproteolyticus. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. See Metalloproteases and Matrix metalloproteinase for discussion. Structural highlights Thermolysin is a well researched metalloprotease containing (click this!) and the amino acids His-Glu-X-His-His as its catalytic center. , holding it fast, while stabilize the substrate protein which will be cleaved into two smaller proteins..

spinqualitylabelsall models PDB ID 2a7g Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Thermolysin3D Structures of Thermolysin

Updated on 25-September-2018

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• Thermolysin
  • 2whz, 3fvp, 3dnz, 3do0, 3do1, 3do2, 2g4z, 2a7g, 1gxw, 1kei, 1l3f, 1tlx, 2tlx, 8tln, 3p7p, 3p7q, 3p7r, 3p7s, 3p7t, 3p7u, 3p7v, 3p7w, 3zi6, 5dlh, 5tli, 6tli, 7tli, 8tli, 5un3, 5uu7, 5wr2, 5wr3, 5wr4, 5wr5, 5wr6, 5a3y, 5o8n, 5uu8, 5uu9, 5uua, 5uub, 5uuc, 5uud, 5uue, 5fsj, 5fsp, 5fss, 5fxn, 5t9i, 5t9k, 5t9q, 5tac, 5tad, 5tae, 5tai, 5taj, 5tak, 5hqd, 6tli, 7tli, 8tli, 6d5o, 6fsm, 6d5p, 6d5q, 6d5r, 6d5s, 6d5t, 6d5u, 6fj2 – TML
    
  • 5dlh – TML - electron crystallography
    
  • 3ls7, 4ow3, 4tnl - TML residues 233-548
    
  • 1trl - TML residues 255-316 – NMR
    
  • 3fxs, 3fbo, 3eim, 1lna, 1lnb, 1lnc, 1lnd, 1lne, 1lnf - TML residues 233-548+metal ion replacing Ca
    
• Thermolysin TML+transition state analog
  • 1tlp, 1tmn, 2tmn, 4tmn, 5tmn – TML+transition state analog
    
• Thermolysin + amino acid
  • 1kl6 – TML+ alanine
    
  • 4m65 – TML + asparagine
    
  • 8tln – TML+ avaline + lysine
    
  • 3qgo – TML + phenylalanine methyl ester
    
  • 3qh1 – TML + benzyloxycarboxyl- aspartate
    
  • 3qh5 – TML + benzyloxycarboxyl- aspartate + phenylalanine methyl ester
• Thermolysin + dipeptide
  • 2wi0, 3tmn, 8tln – TML+ dipeptide
    
  • 3fgd - TML residues 233-548+dipeptide
    
• Thermolysin + inhibitor
  • 1fjo, 1fj3, 1fjq, 1fjt, 1fju, 1fjv, 1fjw, 4tli, 5tli, 6tli, 7tli, 8tli, 1tli, 2tli, 3tli – TML soaked in organic solvents
    
  • 3fv4, 3fxp, 3flf, 3fb0, 3fcq, 3f28, 3f2p, 4mtw, 4mwp, 4mxj, 4mzn, 4n4e, 4n5p, 4n66, 4oi5 – TML residues 233-548+inhibitor
    
  • 3for, 1y3g, 1zdp, 1z9g, 1pes, 1pe7, 1pe8, 1os0, 1kto, 1ks7, 1kro, 1kr6, 1kkk, 1kjo, 1kjp, 1qf0, 1qf1, 1qf2, 1hyt, 1thl, 6tmn, 7tln, 4tln, 5tln, 1pe5, 3ms3, 3msa, 3msf, 3msn, 3n21, 3nn7, 3t73, 3t74, 3t87, 3t8c, 3t8d, 3t8f, 3t8g, 3t8h, 4h57, 4d9w, 4d91, 5dpe, 5dpf, 5js3, 5jss, 5jt9, 5jvi, 5jxn, 5lif, 5lvd, 5lwd, 5m5f, 5m69, 5mnr, 5n2t, 5n2x, 5n2z, 5n31, 5n34, 5n3v, 5n3y, 5ma7, 5l3u, 5l41, 5l8p, 5m9w, 6tmn, 7tln, 5tln, 5tmn, 5wr2, 5wr3, 5wr4, 5wr5, 5wr6 – TML+inhibitor
    
  • 3ssb – TML + Impi-α
    
  • 3t2h – TML + trimethylamine oxide
    
  • 3t2i – TML + sarcosine
    
  • 3t2j – TML + betaine
    
  • 6fhp – TML C terminal + DAIP