Stepler sandbox STAT3
STAT3STAT3
STAT3 (Signal Transducer and Activator of Transcription 3) is one of seven of a family of homologous STAT proteins that differentially regulate gene expression. STAT 3 is important in both the development of embryos and many functions in adult organisms. The STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. [1] StructureThe STAT3 protein is composed of several helix-turn-helix structures and its quaternary structure consists of two STAT3 proteins dimerized with themselves. [2] RegulationDNA-Protein InteractionsThe by binding to the major groove of the DNA. Structural highlightsThis is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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ReferencesReferences
- ↑ Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502. PMID:11050435
- ↑ Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298 doi:10.1038/28101