FunctionTumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF[1]. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains.
- TNFRSF 1 is called Lymphotoxin-α or TNF-β;
- TNFRSF 3 is called TNFR-III;
- TNFRSF 4 is called OX40L receptor;
- TNFRSF 5 is called CD40L receptor;
- TNFRSF 6 is called Fas;
- TNFRSF 9 is called 4-1BBL;
- TNFRSF 10B is called Dr5;
- TNFRSF 11 is called RANKL;
- TNFRSF 11A is called RANK;
- TNFRSF 11B is called Osteoprotegerin;
- TNFRSF 12 is called TWEAK;
- TNFRSF 12A is called TWEAKR;
- TNFRSF 13 is called APRIL;
- TNFRSF 13B is called BAFF or sTALL-1;
- TNFRSF 13C is called BAFF receptor;
- TNFRSF 14 is called LIGHT;
- TNFRSF 16 is called Nerve growth factor receptor;
- TNFRSF 18 is called GITRL;
- TNFRSF 21 is called Dr6;
DiseaseRelevanceStructural highlights | |
3D structures of tumor necrosis factor receptor3D structures of tumor necrosis factor receptor
Updated on 28-September-2016
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- Tumor necrosis factor receptor 1
- 1ncf – hTNFR-1 residues 12-172 (mutant) – human
- 1ich – hTNFR-1 death domain (mutant) - NMR
- 2eqp – hTNFR-1 residues 28-70 – NMR
- 1ext – hTNFR-1 extracellular domain
- 1ft4 – hTNFR-1 extracellular domain + inhibitor
- 3on9 – evTNFR SECRET domain – ectromelia virus
- 3ona – evTNFR SECRET domain + CX3CL1
- Tumor necrosis factor receptor superfamily 1 (lymphotoxin-α, TNF-β)
- 1tnr – hTNFRSF-1 + TNFβ
- 4mxv – hTNFSF-1 extracellular domain + antibody - human
- 4mxw – hTNFSF-1 extracellular domain + antibody + TNFR-III
- Tumor necrosis factor receptor superfamily 1B
- 3alq – hTNFRSF-1B extracellular domain + TNF
- Tumor necrosis factor receptor superfamily-4 (OX40L receptor)
- 2hew – mTNFSF-4 extracellular domain - mouse
- 2hev – hTNFSF-4 extracellular domain + OX40 ligand
- 2hey – mTNFSF-4 extracellular domain + hOX40 ligand
- Tumor necrosis factor receptor superfamily-5 (CD40L receptor)
- 1aly – hTNFSF-5 extracellular domain
- 1i9r – hTNFSF-5 extracellular domain + antibody
- 3lkj – hTNFSF-5 extracellular domain + inhibitor
- 3qd6 – hTNFRSF-5 extracellular domain + CD40 ligand
- Tumor necrosis factor receptor superfamily-6 (Fas)
- 3thm, 3tje – hTNFRSF-6 extracellular domain + antibody
- 3ezq – hTNFRSF-6 Fas DD domain + FADD
- 3oq9 – mTNFRSF-6 Fas DD domain + FADD - mouse
- Tumor necrosis factor receptor superfamily-6B
- 3mhd – hTNFRSF-6B extracellular domain
- 4msv – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain
- 4kgg, 4kgq, 4j6g – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain
- 3mi8 – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain
- 3k51 – hTNFRSF-6B cysteine-rich domain + hTNFRSF-15 extracellular domain
- Tumor necrosis factor receptor superfamily-10B (Dr5)
- 2h9g, 4od2, 1za3 – hTNFRSF-10B extracellular domain + antibody
- 1d0g – hTNFRSF-10B extracellular domain + apoptosis-2 ligand
- 1d4v – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand
- 4i9x – hTNFRSF-10B extracellular domain + UL141
- 4n90 – hTNFRSF-10B + hTNFRSF-10 + antibody
- Tumor necrosis factor receptor superfamily-9 (4-1BBL)
- 2x29 – hTNFSF-9 extracellular domain (mutant)
- Tumor necrosis factor receptor superfamily-11 (RANKL)
- 1jtz, 1iqa, 1s55 – mTNFSF-11 receptor-binding domain
- 3me2, 3qbq, 4giq – mTNFSF-11 receptor-binding domain + RANK
- 4e4d – mTNFSF-11 receptor-binding domain + osteoprotegerin
- 3urf – hTNFSF-11 receptor-binding domain + osteoprotegerin
- Tumor necrosis factor receptor superfamily-11A (RANK)
- 3me4 – mTNFRSF-11A extracellular domain
- Tumor necrosis factor receptor superfamily-11B (Osteoprotegerin)
- 3urf – hTNFRSF-11B extracellular domain + TNFRSF-11B ligand
- 4e4d – mTNFRSF-11B extracellular domain + TNFRSF-11B ligand
- TNFSF-12 superfamily member 12 (TWEAK)
- 4ht1 – hTNFSF-12 extracellular domain + antibody
- Tumor necrosis factor receptor superfamily-12A (TWEAKR)
- TNFSF-13 superfamily member 13 (APRIL)
- 1u5x, 1u5y, 1u5z – mTNFSF-13 extracellular domain
- 1xu1 – mTNFSF-13 extracellular domain + TNFSF-13B
- 1xu2 – mTNFSF-13 extracellular domain + BCMA
- 3k48 – mTNFSF-13 extracellular domain + peptide
- 4zch – hTNFSF-13 extracellular domain + TNFSF-13B
- TNFSF-13B superfamily member 13B (BAFF, sTALL-1)
- 1jh5, 1kxg, 1kd7, 4zch – hTNFSF-13B extracellular domain
- 1oqd – hTNFSF-13B extracellular domain + B-cell maturation protein
- 1oqe – hTNFSF-13B extracellular domain + hTNFRSF-13C
- 4v46 – hTNFSF-13B extracellular domain + hTNFRSF-13C + BAFF
- 1osg, 3v56 – hTNFSF-13B extracellular domain + hTNFRSF-13C peptide
- Tumor necrosis factor receptor superfamily-13C (BAFF receptor)
- 1osx – hTNFRSF-13C extracellular domain - NMR
- 2hfg – hTNFL cysteine-rich domain + antibody
- Tumor necrosis factor receptor superfamily-14 (LIGHT)
- 4fhq, 4en0 – hTNFRSF-14 extracellular domain
- 2aw2 – hTNFRSF-14 extracellular domain + B and T lymphocyte attenuator
- 4rsu – hTNFRSF-14 extracellular domain + TNFRSF-14 ligand
- 4kg8 – hTNFSF-14 extracellular domain (mutant)
- 4j6g – hTNFSF-14 extracellular domain + DCR3
- 4kgq, 4kgg – hTNFSF-14 extracellular domain (mutant) + DCR3
- Tumor necrosis factor receptor superfamily-16 (nerve growth factor receptor)
- 4f42, 4f44 – hTNFRSF-16 death domain
- 1sg1, 3ij2 – hTNFRSF-16 + beta nerve growth factor
- 3buk – hTNFRSF-16 + neurotrophin-3
- Tumor necrosis factor receptor superfamily-17
- 2kn1 – hTNFRSF-17 extracellular domain - NMR
- 4zfo – hTNFRSF-17 extracellular domain + antibody
- Tumor necrosis factor receptor superfamily-18 (GITRL)
- Tumor necrosis factor receptor superfamily-21 (Dr6)
- 3u3p, 3u3q, 3u3s, 3u3t, 3u3v – hTNFRSF-21 cysteine-rich domain
- 2dbh – hTNFRSF-21 CARD-like domain - NMR
- 3qo4 – hTNFRSF-21 cysteine-rich domain
- 4yn0 – hTNFRSF-21 cysteine-rich domain + amyloid beta A4 protein
ReferencesReferences