THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNATHE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
Structural highlights
1nhm is a 1 chain structure with sequence from Cricetulus griseus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
[HMGB1_CRIGR] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
