3k7e

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Crystal structure of human ligand-free mature caspase-6Crystal structure of human ligand-free mature caspase-6

Structural highlights

3k7e is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:CASP6, MCH2 (Homo sapiens)
Activity:Caspase-6, with EC number 3.4.22.59
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

See Also

3k7e, resolution 3.00Å

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