Integrin

Integrins (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.

spinqualitylabelsall models Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of integrin3D structures of integrin

Updated on 27-November-2014

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• IG CR3
  • 1ido – hIG I domain + Mg – human
    
  • 1jlm - hIG I domain + Mn
    
• IG CD11a or IG α-L
  • 1lfa - hIG I domain + Mn
    
  • 1zon - hIG I domain
    
  • 1zoo, 1zop, 3f74 - hIG I domain + Mg
    
  • 1mq9 - hIG I domain (mutant) + Mn
    
  • 1mjn - hIG I domain (mutant) + Mg
    
  • 1mqa - hIG I domain (mutant)
    
  • 2k8o – hIG cytoplasmic domain (mutant) – NMR
    
• IG CD11a complexes
  • 1cqp - hIG I domain + lovastatin + Mg
    
  • 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
    
  • 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
    
  • 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
    
  • 2o7n, 3m6f - hIG I domain + antagonist
    
  • 1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
    
  • 4ixd - hIG I domain + activator + Mg
    
  • 3f78 - hIG I domain + anesthetic + Mg
    
  • 3eoa, 3eob - hIG I domain + antibody
    
  • 3hi6 - hIG I domain (mutant) + antibody + Mn
    
• IG CD11b
  • 1bho - hIG I domain + Mg
    
  • 1bhq - hIG I domain + Cd
    
  • 1m1u - hIG I domain (mutant) + Ca
    
  • 1n9z - hIG I domain (mutant) + Mg
    
  • 1idn, 1na5 - hIG I domain
    
  • 1mf7 - hIG I domain (mutant)
• IG CD11c
  • 1n3y - hIG I domain (mutant)
• IG α-1 (CD49a)
  • 1ck4 - rIG I domain – rat
    
  • 4a0q - hIG I domain (mutant) + Mg
    
  • 2l8s - hIG transmembrane domain – NMR
    
  • 1mhp - rIG I domain (mutant) + antibody + Mn
    
  • 2b2x - rIG I domain (mutant) + antibody + Mg
    
  • 2m32 - hIG I domain + collagen peptide
    
• IG α-2 (CD49b)
  • 1dzi, 4bj3 - hIG I domain + collagen peptide
    
  • 1v7p - hIG I domain (mutant) + EMS16 + Mn
    
• IG α-2b
  • 2k1a - hIG transmembrane domain – NMR
    
• IG α-1 β-1 (CD49a-CD49b)
  • 1qc5, 1qcy - hIG I domain (mutant) + Mg
    
  • 1pt6 - hIG I domain + Mg
    
• IG α-2 (CD49b) β
  • 1aox - hIG I domain (mutant) + Mg
    
  • 1s4w - hIG cytoplasmic domain]] - NMR
    
• IG α-2b β-3 (CD61)
  • 1kup, 1kuz – hIG proximal domain – NMR
    
  • 1m8o - hIG cytoplasmic domain – NMR
    
  • 4cak – hIG – Cryo-EM
    
  • 2k9j, 2knc - hIG transmembrane domain – NMR
    
  • 1tye, 3fcu, 3fcs – hIG + Mg
    
  • 3fc3 – hIG (mutant) + Mg
    
  • 2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig, 3zdx, 3zdy, 3zdz, 3ze0, 3ze1, 3ze2 – hIG headpiece + antibody + Mg
    
  • 2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
    
  • 2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
    
• IG α-4

• • 4irz - hIG + antibody
    
• IG α-4 (CD49d) β-7
  • 3v4p - hIG headpiece (mutant) + antibody + Mg
    
  • 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
    
• IG α-5 (CD49e) β-1 (CD29)
  • 3vi3 - hIG headpiece + antibody + Mg
    
  • 3vi4 - hIG headpiece + antibody + peptide + Mg
    
• IG α-5 (CD49e) β-3 (CD61)
  • 3ije – hIG + Ca
    
  • 1m1x - hIG extracellular domain + Mn
    
  • 1u8c – hIG psi domain + Ca
    
  • 1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
    
  • 1l5g - hIG I domain + tripeptide + Mn
    
• IG α-M
  • 3q3g, 3qa3 – hIG + antibody
    
  • 2lke, 2lkj – hIG cytoplasmic domain – NMR
    
• IG α-X
  • 2luv – hIG cytoplasmic domain – NMR
    
• IG α-X β-2 (CD18)
  • 3k6s, 3k71, 3k72 – hIG + Mg
    
  • 4neh, 4nen – hIG (mutant) + Mg
    
• IG α-V β-3
  • 4g1e, 4g1m – hIG + Ni
    
• IG β-1D
  • 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
    
• IG β-2 (CD18)
  • 2p26, 2p28 – hIG phe2 + phe3 domains
    
  • 1yuk – hIG chain A PSI domain + chain B I-EGF domain
    
• IG β-3 (CD61)
  • 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
    
  • 2rmz, 2rn0 – hIG transmembrane domain – NMR
    
  • 2l91 - hIG transmembrane domain (mutant) – NMR
    
  • 2l1c – hIG cytoplasmic tail + SHC
    
• IG β-4 (CD104)
  • 2f7q, 3f7r, 1qg3, 3f7q - hIG fibronectin type III domain
    
  • 2yrz – hIG fibronectin type III domain – NMR
    
  • 3f7p - hIG fibronectin type III domain + plectin-1 + Ca
    
  • 3fq4, 3fso, 3h6a – hIG Calx-β domain