Glyoxalase

Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism.

• GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
  
• GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.

3D structures of glyoxalase3D structures of glyoxalase

Updated on 26-November-2014

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• Glyoxalase 1
  • 1bh5 – hGLO (mutant) – human
    
  • 1fa8 – EcGLO – Escherichia coli
    
  • 2c21 – GLO – Leishmania major
    
  • 1fro – hGLO + benzyl glutathione
    
  • 1qin, 1qip - hGLO + glutathione derivative
    
  • 1f9z, 1fa5, 1fa6, 1fa7 – EcGLO + metal
    
  • 2za0 – GLO + methyl gerfelin – mouse
    
  • 3hdp – GLO + Ni – Clostridium acetobutylicum
• Glyoxalase 2
  • 1xm8 – GLO – Arabidopsis thaliana
    
  • 2p18 - LiGLO – Leishmania infantum
    
  • 1qh3 – hGLO + actate + cacodylate
    
  • 1qh5 – hGLO + glutathione derivative
    
  • 2p1e – LiGLO + lactate
• Glyoxalase 3
  • 4lru – GLO – Candida albicans