Talin

Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

3D Structures of Talin3D Structures of Talin

Updated on 24-September-2014

Talin subdomainsTalin subdomains

2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse
2kma – mTal F0F1 – NMR
2kc1 - mTal F0 – NMR
2kc2 - mTal F1 – NMR
2hrj - cTal F2 – NMR
1mix – cTal F2F3
4f7g - mTal F2F3 + rod segment domain
2kgx – mTal F3+mTal fragment – NMR
3ivf – mTal FERM domain
2l7n – mTal B – NMR
2l10 – mTal C - NMR
2lqg - mTal R4 helix – NMR

Talin integrin-binding sitesTalin integrin-binding sites

2jsw, 2qdq – mTal IBS – NMR
3g9w – mTal2 F2F3+integrin tail
1miz, 1mk7, 1mk9 - hTal+integrin tail
2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
3fyq – Tal rod IBS2 – Drosophila melanogaster

Talin vinculin-binding sitesTalin vinculin-binding sites

2kvp, 2b0h – mTal VBS3 – NMR
1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
1u6h - cTal VBS2+ vinculin head
1t01 - cTal VBS1+ vinculin head
1syq - hTal VBS1+ vinculin head – human
1rkc, 3s90 - hTal VBS3+ vinculin head
1u89, 2l7a - mTal VBS2 – NMR
4dj9 – hTal VBS50 + vinculin head

Talin PIP kinase binding sitesTalin PIP kinase binding sites

1y19 - mTal F2F3+ PIP kinase C-terminal
2g35 - mTal F3+PIP kinase peptide – NMR

Layilin binding sitesLayilin binding sites

2k00 - cTal F3+layilin fragment – NMR