Talin

Talin is involved in cell-cell contacts. It links integrins to actin^[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

3D Structures of Talin3D Structures of Talin

Talin 3D structures

ReferencesReferences

↑ Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

[1] Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235-54. doi: 10.1146/annurev.biophys.050708.133744. PMID:19416068 doi:http://dx.doi.org/10.1146/annurev.biophys.050708.133744

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