4l9i

Bovine G Protein Coupled Receptor Kinase 1 in Complex with ParoxetineBovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine

Template:ABSTRACT PUBMED 24220010

FunctionFunction

[RK_BOVIN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).

About this StructureAbout this Structure

4l9i is a 2 chain structure. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov , 12. PMID:24220010 doi:http://dx.doi.org/10.1124/mol.113.089631

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OCA

[1] Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov , 12. PMID:24220010 doi:http://dx.doi.org/10.1124/mol.113.089631

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