Plasminogen

Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.

3D Structures of plasminogen3D Structures of plasminogen

Plasminogen kringle 1Plasminogen kringle 1

1pkr - hPLG kringle 1 – human
1cea - hPLG kringle 1 + e-aminocaprioic acid
1hpj, 1hpk - hPLG kringle 1 + 6-aminohexanoic acid - NMR
1ceb - hPLG kringle 1 + AMCHA

Plasminogen kringle 2Plasminogen kringle 2

1b2i - hPLG kringle 2 (mutant) – NMR
1i5k - hPLG kringle 2 (mutant) + M2 protein peptide
2kj4 – hPLG kringle 2 + M2 protein peptide – NMR

Plasminogen kringle 3Plasminogen kringle 3

2l0s - hPLG kringle 3 – NMR

Plasminogen kringle 4Plasminogen kringle 4

1pk4, 1pmk, 1pml, 1krn – hPLG kringle 4
2pk4 - hPLG kringle 4 + e-aminocaprioic acid

Plasminogen kringle 5Plasminogen kringle 5

5hpg - hPLG kringle 5
2knf - hPLG kringle 5 – NMR

Plasminogen catalytic domainPlasminogen catalytic domain

1qrz, 1ddj, 1rjx – hPLG catalytic domain (mutant)

PlasminPlasmin

1bml – hPLN catalytic domain + streptokinase
1bui – hPLN light chain + staphylokinase