Plasminogen

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Function

Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin.

  • Microplasmin induces posterior vitreous detachment from the retina (PVD)[1].

Disease

PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces[2].

Structural highlights

which are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The , e.g. . The kringle domain is important in protein-protein interaction with blood coagulation factors.[3].

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3D Structures of plasminogen

Plasminogen 3D structures


Human glycosylated plasminogen complex with acetate, bicarbonate, K+ (purple) and Cl- (green) ions (PDB entry 4dur)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Goldenberg DT, Giblin FJ, Cheng M, Chintala SK, Trese MT, Drenser KA, Ruby AJ. Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes. Retina. 2011 Feb;31(2):393-400. doi: 10.1097/IAE.0b013e3181e586b2. PMID:21099453 doi:http://dx.doi.org/10.1097/IAE.0b013e3181e586b2
  2. ↑ Mehta R, Shapiro AD. Plasminogen deficiency. Haemophilia. 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID:19141167 doi:http://dx.doi.org/10.1111/j.1365-2516.2008.01825.x
  3. ↑ Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC. The X-ray crystal structure of full-length human plasminogen. Cell Rep. 2012 Mar 29;1(3):185-90. doi: 10.1016/j.celrep.2012.02.012. Epub 2012, Mar 8. PMID:22832192 doi:10.1016/j.celrep.2012.02.012

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