2bo9: Difference between revisions
New page: left|200px<br /> <applet load="2bo9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bo9, resolution 1.60Å" /> '''HUMAN CARBOXYPEPTID... |
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==About this Structure== | ==About this Structure== | ||
2BO9 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG, ZN, VAL, MPD and ACN as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 2BK7. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BO9 OCA]]. | 2BO9 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG, ZN, VAL, MPD and ACN as [[http://en.wikipedia.org/wiki/ligands ligands]]. This structure superseeds the now removed PDB entry 2BK7. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BO9 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: x-ray crystal structure]] | [[Category: x-ray crystal structure]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:24:07 2007'' | ||
Revision as of 09:19, 30 October 2007
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HUMAN CARBOXYPEPTIDASE A4 IN COMPLEX WITH HUMAN LATEXIN.
OverviewOverview
The only endogenous protein inhibitor known for metallocarboxypeptidases, (MCPs) is latexin, a 25-kDa protein discovered in the rat brain. Latexin, alias endogenous carboxypeptidase inhibitor, inhibits human CPA4 (hCPA4), whose expression is induced in prostate cancer cells after treatment with, histone deacetylase inhibitors. hCPA4 is a member of the A/B subfamily of, MCPs and displays the characteristic alpha/beta-hydrolase fold. Human, latexin consists of two topologically equivalent subdomains, reminiscent, of cystatins, consisting of an alpha-helix enveloped by a curved, beta-sheet. These subdomains are packed against each other through the, helices and linked by a connecting segment encompassing a third, alpha-helix. The enzyme is bound at the interface of these subdomains. The, ... [(full description)]
About this StructureAbout this Structure
2BO9 is a [Protein complex] structure of sequences from [Homo sapiens] with NAG, ZN, VAL, MPD and ACN as [ligands]. This structure superseeds the now removed PDB entry 2BK7. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin., Pallares I, Bonet R, Garcia-Castellanos R, Ventura S, Aviles FX, Vendrell J, Gomis-Ruth FX, Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3978-83. Epub 2005 Feb 28. PMID:15738388
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