2efg: Difference between revisions
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{{STRUCTURE_2efg| PDB=2efg | SCENE= }} | |||
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'''TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP''' | '''TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP''' | ||
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[[Category: Steitz, T A.]] | [[Category: Steitz, T A.]] | ||
[[Category: Wang, J.]] | [[Category: Wang, J.]] | ||
[[Category: | [[Category: Elongation]] | ||
[[Category: | [[Category: Elongation factor]] | ||
[[Category: | [[Category: Gtp binding]] | ||
[[Category: | [[Category: Gtpase]] | ||
[[Category: | [[Category: Guanosine nucleotide binding]] | ||
[[Category: | [[Category: Protein synt factor]] | ||
[[Category: | [[Category: Ribosome]] | ||
[[Category: | [[Category: Translation]] | ||
[[Category: | [[Category: Translocase]] | ||
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Revision as of 02:28, 4 May 2008
TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP
OverviewOverview
Elongation factor G (EF-G) catalyzes the translocation step of protein synthesis in bacteria, and like the other bacterial elongation factor, EF-Tu--whose structure is already known--it is a member of the GTPase superfamily. We have determined the crystal structure of EF-G--GDP from Thermus thermophilus. It is an elongated molecule whose large, N-terminal domain resembles the G domain of EF-Tu, except for a 90 residue insert, which covers a surface that is involved in nucleotide exchange in EF-Tu and other G proteins. The tertiary structures of the second domains of EF-G and EF-Tu are nearly identical, but the relative placement of the first two domains in EF-G--GDP resembles that seen in EF-Tu--GTP, not EF-Tu--GDP. The remaining three domains of EF-G look like RNA binding domains, and have no counterparts in EF-Tu.
About this StructureAbout this Structure
2EFG is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution., Czworkowski J, Wang J, Steitz TA, Moore PB, EMBO J. 1994 Aug 15;13(16):3661-8. PMID:8070396 Page seeded by OCA on Sun May 4 02:28:16 2008