NADPH dehydrogenase: Difference between revisions
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== Function == | == Function == | ||
'''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. '''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones. | '''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. | ||
*'''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones. | |||
== Structural highlights == | == Structural highlights == | ||
<scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres. | <scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres. | ||