4mik: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mik]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MIK FirstGlance]. <br> | <table><tr><td colspan='2'>[[4mik]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MIK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JIL:9-{5-S-[2-({[(3S)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHYL}AMINO)ETHYL]-5-THIO-ALPHA-L-LYXOFURANOSYL}-9H-PURIN-6-AMINE'>JIL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9506Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JIL:9-{5-S-[2-({[(3S)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHYL}AMINO)ETHYL]-5-THIO-ALPHA-L-LYXOFURANOSYL}-9H-PURIN-6-AMINE'>JIL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mik OCA], [https://pdbe.org/4mik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mik RCSB], [https://www.ebi.ac.uk/pdbsum/4mik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mik ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mik OCA], [https://pdbe.org/4mik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mik RCSB], [https://www.ebi.ac.uk/pdbsum/4mik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mik ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 14:09, 6 November 2024
Crystal Structure of hPNMT in Complex with bisubstrate inhibitor (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-(((7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diolCrystal Structure of hPNMT in Complex with bisubstrate inhibitor (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-(((7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diol
Structural highlights
FunctionPNMT_HUMAN Converts noradrenaline to adrenaline. See Also |
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