Phenylethanolamine N-methyltransferase

Function

Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline^[1]. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT.

Relevance

PNMT activity is decreased in Alzheimer disease patients^[2].

Structural highlights

The active site of PNMT contains the and ^[3]. Water molecules are shown as red spheres. .

Human phenylethanolamine N-methyltransferase with adenosyl homocysteine complex with substrate noradrenochrome (PDB entry 3hcb)

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3D Structures of Phenylethanolamine N-methyltransferase3D Structures of Phenylethanolamine N-methyltransferase

Updated on 23-August-2023

3kpj – hPNMT+AdoHcy – human
3kpu, 3kpv, 3kpw, 3kpy, 3kqm, 3kqo, 3kqp, 3kqq, 3kqs, 3kqt, 3kqv, 3kqw, 3kqy, 3kr0, 3kr1, 3kr2, 3hcb, 3hcc, 3hcf, 2ony, 2g70, 2g71, 2g8n, 2an5, 1yz3, 1n7i, 1n7j, 1hnn, 6ws1, 7two, 7tx2 - hPNMT+AdoHcy+ligand
3hca, 3hce, 2obf, 2onz, 2obp - hPNMT (mutant)+AdoHcy+ligand
3hcd - hPNMT+AdoHcy+noradrenaline
2g72 - hPNMT+AdoMet+ligand
2opb - hPNMT+AdoMet + inhibitor
2an3 - hPNMT+AdoHcy+substrate analog
2an4 - hPNMT+AdoHcy+octopamine
4dm3 - hPNMT+AdoHcy + resorcinol + imidazole
4mik, 4mq4 – hPNMT + inhibitor

ReferencesReferences

↑ Martin JL, Begun J, McLeish MJ, Caine JM, Grunewald GL. Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT. Structure. 2001 Oct;9(10):977-85. PMID:11591352
↑ Burke WJ, Chung HD, Nakra BR, Grossberg GT, Joh TH. Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer's disease brains. Ann Neurol. 1987 Aug;22(2):278-80. PMID:3662456 doi:http://dx.doi.org/10.1002/ana.410220216
↑ Drinkwater N, Gee CL, Puri M, Criscione KR, McLeish MJ, Grunewald GL, Martin JL. Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem J. 2009 Aug 27;422(3):463-71. PMID:19570037 doi:10.1042/BJ20090702

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Alexander Berchansky, Michal Harel

[1] Martin JL, Begun J, McLeish MJ, Caine JM, Grunewald GL. Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT. Structure. 2001 Oct;9(10):977-85. PMID:11591352

[2] Burke WJ, Chung HD, Nakra BR, Grossberg GT, Joh TH. Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer's disease brains. Ann Neurol. 1987 Aug;22(2):278-80. PMID:3662456 doi:http://dx.doi.org/10.1002/ana.410220216

[3] Drinkwater N, Gee CL, Puri M, Criscione KR, McLeish MJ, Grunewald GL, Martin JL. Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem J. 2009 Aug 27;422(3):463-71. PMID:19570037 doi:10.1042/BJ20090702

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