Inorganic pyrophosphatase: Difference between revisions
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'''Inorganic pyrophosphatase''' (PPase) catalyzes the breakdown of pyrophosphate (PPi) to two molecules of phosphate (PO4). The reaction releases energy and is irreversible hence it is coupled to biochemical reactions which need to be driven to completion. PPase plays a role in lipid metabolism, calcium absorption, bone formation and DNA synthesis. PPase requires a divalent metal ion like Mg+2 for higher activity. PPi is formed in many biosynthetic reactions which require ATP<ref>PMID:5342521</ref>. | '''Inorganic pyrophosphatase''' (PPase) catalyzes the breakdown of pyrophosphate (PPi) to two molecules of phosphate (PO4). The reaction releases energy and is irreversible hence it is coupled to biochemical reactions which need to be driven to completion. PPase plays a role in lipid metabolism, calcium absorption, bone formation and DNA synthesis. PPase requires a divalent metal ion like Mg+2 for higher activity. PPi is formed in many biosynthetic reactions which require ATP<ref>PMID:5342521</ref>. | ||
*'''NADH pyrophosphatase''' catalyzes the hydrolysis of the phosphate bond of NADH to reduced mononucleotide<ref>PMID:37082214</ref>. | *'''NADH pyrophosphatase''' catalyzes the hydrolysis of the phosphate bond of NADH to reduced mononucleotide<ref>PMID:37082214</ref>. | ||
*'''proton pyrophosphatase''' functions in the regulation of pyrophosphates in plants. Enhanced expression increases yields in crops<ref>PMID:31081197</ref>. | |||
== Structural highlights == | == Structural highlights == | ||