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==== | ==Structure of the Marseillevirus nucleosome== | ||
<StructureSection load='7lv8' size='340' side='right'caption='[[7lv8]]' scene=''> | <StructureSection load='7lv8' size='340' side='right'caption='[[7lv8]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7lv8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Marseillevirus_marseillevirus Marseillevirus marseillevirus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LV8 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lv8 OCA], [https://pdbe.org/7lv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lv8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lv8 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lv8 OCA], [https://pdbe.org/7lv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lv8 RCSB], [https://www.ebi.ac.uk/pdbsum/7lv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lv8 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hbeta-Halpha and Hdelta-Hgamma from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes. | |||
The structure of a virus-encoded nucleosome.,Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ Nat Struct Mol Biol. 2021 May;28(5):413-417. doi: 10.1038/s41594-021-00585-7. , Epub 2021 Apr 29. PMID:33927388<ref>PMID:33927388</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7lv8" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Marseillevirus marseillevirus]] | ||
[[Category: Synthetic construct]] | |||
[[Category: Abini-Agbomson S]] | |||
[[Category: Armache K-J]] | |||
[[Category: Valencia-Sanchez MI]] | |||
Latest revision as of 12:28, 9 October 2024
Structure of the Marseillevirus nucleosomeStructure of the Marseillevirus nucleosome
Structural highlights
Publication Abstract from PubMedCertain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hbeta-Halpha and Hdelta-Hgamma from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes. The structure of a virus-encoded nucleosome.,Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ Nat Struct Mol Biol. 2021 May;28(5):413-417. doi: 10.1038/s41594-021-00585-7. , Epub 2021 Apr 29. PMID:33927388[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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