Structure of the Marseillevirus nucleosomeStructure of the Marseillevirus nucleosome

Structural highlights

7lv8 is a 10 chain structure with sequence from Marseillevirus marseillevirus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hbeta-Halpha and Hdelta-Hgamma from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.

The structure of a virus-encoded nucleosome.,Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ Nat Struct Mol Biol. 2021 May;28(5):413-417. doi: 10.1038/s41594-021-00585-7. , Epub 2021 Apr 29. PMID:33927388[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Valencia-Sánchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ. The structure of a virus-encoded nucleosome. Nat Struct Mol Biol. 2021 May;28(5):413-417. PMID:33927388 doi:10.1038/s41594-021-00585-7

7lv8, resolution 3.40Å

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