Cell death protein: Difference between revisions

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*'''CED-1''' is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> CED-1 and CED-L1 complex with glycerol</scene> ([[3bik]]).
*'''CED-1''' is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> CED-1 and CED-L1 complex with glycerol</scene> ([[3bik]]).
*'''CED-3''' is a cysteine protease involved in apoptosis<ref>PMID:8654923</ref>.
*'''CED-3''' is a cysteine protease involved in apoptosis<ref>PMID:8654923</ref>.
*CED-4 attenuates tumorigenesis by translational contro<ref>PMID:29806708</ref>.  lFor details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'><ref>PMID:18287011</ref>.  
*'''CED-4''' attenuates tumorigenesis by translational contro<ref>PMID:29806708</ref>.  lFor details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'><ref>PMID:18287011</ref>.  
*For details on '''CED-8''' see [[Apoptosis-inducing factor]].
*For details on '''CED-8''' see [[Apoptosis-inducing factor]].


Revision as of 11:48, 2 June 2024


Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis.

  • CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. [1] CED-1 and CED-L1 complex with glycerol</scene> (3bik).
  • CED-3 is a cysteine protease involved in apoptosis[2].
  • CED-4 attenuates tumorigenesis by translational contro[3]. lFor details on CED-4 see CED-4 Apoptosome. <scene name='50/507728/Cv/2'>[4].
  • For details on CED-8 see Apoptosis-inducing factor.

Cell death protein 3D structures

Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
  2. ↑ Xue D, Shaham S, Horvitz HR. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 1996 May 1;10(9):1073-83. PMID:8654923 doi:10.1101/gad.10.9.1073
  3. ↑ Wang Q, Yang HS. The role of Pdcd4 in tumour suppression and protein translation. Biol Cell. 2018 May 28:10.1111/boc.201800014. PMID:29806708 doi:10.1111/boc.201800014
  4. ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011

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