6ysl: Difference between revisions
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==== | ==Structure of the flagellar MotAB stator complex from Bacillus subtilis== | ||
<StructureSection load='6ysl' size='340' side='right'caption='[[6ysl]]' scene=''> | <StructureSection load='6ysl' size='340' side='right'caption='[[6ysl]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6ysl]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YSL FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ysl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ysl OCA], [https://pdbe.org/6ysl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ysl RCSB], [https://www.ebi.ac.uk/pdbsum/6ysl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ysl ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MOTA_BACSU MOTA_BACSU] MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The bacterial flagellum is the prototypical protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex. The motor consists of a central rotor surrounded by stator units that couple ion flow across the cytoplasmic membrane to generate torque. Here, we present the structures of the stator complexes from Clostridium sporogenes, Bacillus subtilis and Vibrio mimicus, allowing interpretation of the extensive body of data on stator mechanism. The structures reveal an unexpected asymmetric A5B2 subunit assembly where the five A subunits enclose the two B subunits. Comparison to structures of other ion-driven motors indicates that this A5B2 architecture is fundamental to bacterial systems that couple energy from ion flow to generate mechanical work at a distance and suggests that such events involve rotation in the motor structures. | |||
Structures of the stator complex that drives rotation of the bacterial flagellum.,Deme JC, Johnson S, Vickery O, Muellbauer A, Monkhouse H, Griffiths T, James RH, Berks BC, Coulton JW, Stansfeld PJ, Lea SM Nat Microbiol. 2020 Sep 14. pii: 10.1038/s41564-020-0788-8. doi:, 10.1038/s41564-020-0788-8. PMID:32929189<ref>PMID:32929189</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6ysl" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis subsp. subtilis str. 168]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Deme JC]] | ||
[[Category: Johnson SJ]] | |||
[[Category: Lea SM]] | |||
Latest revision as of 13:21, 22 May 2024
Structure of the flagellar MotAB stator complex from Bacillus subtilisStructure of the flagellar MotAB stator complex from Bacillus subtilis
Structural highlights
FunctionMOTA_BACSU MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity). Publication Abstract from PubMedThe bacterial flagellum is the prototypical protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex. The motor consists of a central rotor surrounded by stator units that couple ion flow across the cytoplasmic membrane to generate torque. Here, we present the structures of the stator complexes from Clostridium sporogenes, Bacillus subtilis and Vibrio mimicus, allowing interpretation of the extensive body of data on stator mechanism. The structures reveal an unexpected asymmetric A5B2 subunit assembly where the five A subunits enclose the two B subunits. Comparison to structures of other ion-driven motors indicates that this A5B2 architecture is fundamental to bacterial systems that couple energy from ion flow to generate mechanical work at a distance and suggests that such events involve rotation in the motor structures. Structures of the stator complex that drives rotation of the bacterial flagellum.,Deme JC, Johnson S, Vickery O, Muellbauer A, Monkhouse H, Griffiths T, James RH, Berks BC, Coulton JW, Stansfeld PJ, Lea SM Nat Microbiol. 2020 Sep 14. pii: 10.1038/s41564-020-0788-8. doi:, 10.1038/s41564-020-0788-8. PMID:32929189[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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