1zo0: Difference between revisions
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==NMR structure of antizyme isoform 1 from rat== | ==NMR structure of antizyme isoform 1 from rat== | ||
<StructureSection load='1zo0' size='340' side='right'caption='[[1zo0 | <StructureSection load='1zo0' size='340' side='right'caption='[[1zo0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zo0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1zo0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZO0 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zo0 OCA], [https://pdbe.org/1zo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zo0 RCSB], [https://www.ebi.ac.uk/pdbsum/1zo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zo0 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zo0 OCA], [https://pdbe.org/1zo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zo0 RCSB], [https://www.ebi.ac.uk/pdbsum/1zo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zo0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/OAZ1_RAT OAZ1_RAT] Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity).<ref>PMID:8166639</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Hackert ML]] | ||
[[Category: | [[Category: Hoffman DW]] | ||
Latest revision as of 11:12, 15 May 2024
NMR structure of antizyme isoform 1 from ratNMR structure of antizyme isoform 1 from rat
Structural highlights
FunctionOAZ1_RAT Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity).[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences |
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