1wf7: Difference between revisions

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==Solution structure of the PDZ domain of Enigma homologue protein==
==Solution structure of the PDZ domain of Enigma homologue protein==
<StructureSection load='1wf7' size='340' side='right'caption='[[1wf7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wf7' size='340' side='right'caption='[[1wf7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WF7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WF7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN 1110001A05 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wf7 OCA], [https://pdbe.org/1wf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1wf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wf7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wf7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wf7 OCA], [https://pdbe.org/1wf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1wf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wf7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wf7 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PDLI5_MOUSE PDLI5_MOUSE]] May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).  
[https://www.uniprot.org/uniprot/PDLI5_MOUSE PDLI5_MOUSE] May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Hayashi, F]]
[[Category: Hayashi F]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Qin, X]]
[[Category: Qin X]]
[[Category: Structural genomic]]
[[Category: Tochio N]]
[[Category: Tochio, N]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Enigma homologue protein]]
[[Category: Pdz domain]]
[[Category: Rsgi]]
[[Category: Unknown function]]

Latest revision as of 16:36, 9 May 2024

Solution structure of the PDZ domain of Enigma homologue proteinSolution structure of the PDZ domain of Enigma homologue protein

Structural highlights

1wf7 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PDLI5_MOUSE May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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