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==NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant==
==NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant==
<StructureSection load='5uke' size='340' side='right'caption='[[5uke]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='5uke' size='340' side='right'caption='[[5uke]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5uke]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UKE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5uke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UKE FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRAK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uke OCA], [https://pdbe.org/5uke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uke RCSB], [https://www.ebi.ac.uk/pdbsum/5uke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uke ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uke OCA], [http://pdbe.org/5uke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uke RCSB], [http://www.ebi.ac.uk/pdbsum/5uke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uke ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN]] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]<ref>PMID:10383454</ref> 
[https://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]<ref>PMID:10383454</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines mRNAs, but the function of PIN1 in upstream signaling pathways in asthma is unknown. Here we show that interleukin receptor associated kinase M (IRAK-M) is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. Upon IL-33-induced airway inflammation, PIN1 is activated for binding with and isomerization of IRAK-M, resulting in IRAK-M nuclear translocation and induction of selected proinflammatory genes in dendritic cells. Thus, the IL-33-PIN1-IRAK-M is an axis critical for dendritic cell activation, type 2 immunity and IL-33 induced airway inflammation.
 
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.,Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP Nat Commun. 2018 Apr 23;9(1):1603. doi: 10.1038/s41467-018-03886-6. PMID:29686383<ref>PMID:29686383</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5uke" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Kwon J]]
[[Category: Kwon, J]]
[[Category: Nicholson LK]]
[[Category: Nicholson, L K]]
[[Category: Asthma]]
[[Category: Death domain]]
[[Category: Innate immunity]]
[[Category: Irak-m]]
[[Category: Transferase]]

Latest revision as of 10:28, 1 May 2024

NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutantNMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant

Structural highlights

5uke is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

IRAK3_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

IRAK3_HUMAN Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2][1]

See Also

References

  1. ↑ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10. PMID:10383454
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