5uke

NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutantNMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant

Structural highlights

5uke is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

IRAK3_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

IRAK3_HUMAN Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]^[1]

References

↑ Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10. PMID:10383454

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OCA

[1] Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10. PMID:10383454

[1]

5uke

NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutantNMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant

Structural highlights

Disease

Function

See Also

References

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5uke

NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutantNMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant

Structural highlights

Disease

Function

See Also

References

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