9bh7: Difference between revisions

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New page: ==Human DNA polymerase theta helicase domain dimer in the apo form== <StructureSection load='9bh7' size='340' side='right'caption='9bh7, resolution 3.50Å' scene='...
 
m Protected "9bh7" [edit=sysop:move=sysop]
 
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Latest revision as of 09:26, 1 May 2024

Human DNA polymerase theta helicase domain dimer in the apo formHuman DNA polymerase theta helicase domain dimer in the apo form

Structural highlights

9bh7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPOLQ_HUMAN Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.[1]

References

  1. ↑ Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003 Nov 1;31(21):6117-26. PMID:14576298

9bh7, resolution 3.50Å

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OCA
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