9bh7

Human DNA polymerase theta helicase domain dimer in the apo formHuman DNA polymerase theta helicase domain dimer in the apo form

Structural highlights

9bh7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPOLQ_HUMAN Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.^[1]

References

↑ Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003 Nov 1;31(21):6117-26. PMID:14576298

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OCA

[1] Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 2003 Nov 1;31(21):6117-26. PMID:14576298

[1]

9bh7

Human DNA polymerase theta helicase domain dimer in the apo formHuman DNA polymerase theta helicase domain dimer in the apo form

Structural highlights

Function

References

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9bh7

Human DNA polymerase theta helicase domain dimer in the apo formHuman DNA polymerase theta helicase domain dimer in the apo form

Structural highlights

Function

References

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