1o6v: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
<StructureSection load='1o6v' size='340' side='right'caption='[[1o6v]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='1o6v' size='340' side='right'caption='[[1o6v]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1o6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O6V FirstGlance]. <br>
<table><tr><td colspan='2'>[[1o6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O6V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o6s|1o6s]], [[1o6t|1o6t]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o6v OCA], [https://pdbe.org/1o6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o6v RCSB], [https://www.ebi.ac.uk/pdbsum/1o6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o6v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o6v OCA], [https://pdbe.org/1o6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o6v RCSB], [https://www.ebi.ac.uk/pdbsum/1o6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o6v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INLA_LISMO INLA_LISMO] Mediates the entry of L.monocytogenes into cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 18: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o6v ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o6v ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Listeria monocytogenes, a food-borne bacterial pathogen, enters mammalian cells by inducing its own phagocytosis. The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. We present the crystal structures of the functional domain of InlA alone and in a complex with the extracellular, N-terminal domain of human E-cadherin (hEC1). The leucine rich repeat (LRR) domain of InlA surrounds and specifically recognizes hEC1. Individual interactions were probed by mutagenesis and analytical ultracentrifugation. These include Pro16 of hEC1, a major determinant for human susceptibility to L. monocytogenes infection that is essential for intermolecular recognition. Our studies reveal the structural basis for host tro-pism of this bacterium and the molecular deception L. monocytogenes employs to exploit the E-cadherin system.
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.,Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW Cell. 2002 Dec 13;111(6):825-36. PMID:12526809<ref>PMID:12526809</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1o6v" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lismo]]
[[Category: Listeria monocytogenes EGD-e]]
[[Category: Beier, V]]
[[Category: Beier V]]
[[Category: Chakraborty, T]]
[[Category: Chakraborty T]]
[[Category: Domann, E]]
[[Category: Domann E]]
[[Category: Heinz, D W]]
[[Category: Heinz DW]]
[[Category: Machner, M P]]
[[Category: Machner MP]]
[[Category: Schubert, W D]]
[[Category: Schubert W-D]]
[[Category: Urbanke, C]]
[[Category: Urbanke C]]
[[Category: Wehland, J]]
[[Category: Wehland J]]
[[Category: Ziehm, T]]
[[Category: Ziehm T]]
[[Category: Bacterial infection]]
[[Category: Cell adhesion]]
[[Category: Cell wall attached]]
[[Category: Extracellular recognition]]
[[Category: Leucine rich repeat]]

Revision as of 11:55, 10 April 2024

Internalin (INLA, Listeria monocytogenes) - functional domain, uncomplexedInternalin (INLA, Listeria monocytogenes) - functional domain, uncomplexed

Structural highlights

1o6v is a 2 chain structure with sequence from Listeria monocytogenes EGD-e. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

INLA_LISMO Mediates the entry of L.monocytogenes into cells.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1o6v, resolution 1.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1o6v&oldid=4126411"