6cjo: Difference between revisions

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<StructureSection load='6cjo' size='340' side='right'caption='[[6cjo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6cjo' size='340' side='right'caption='[[6cjo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6cjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Alfalfa Alfalfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CJO FirstGlance]. <br>
<table><tr><td colspan='2'>[[6cjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CJO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHI1, CHI-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3879 Alfalfa])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chalcone_isomerase Chalcone isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.6 5.5.1.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cjo OCA], [https://pdbe.org/6cjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cjo RCSB], [https://www.ebi.ac.uk/pdbsum/6cjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cjo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cjo OCA], [http://pdbe.org/6cjo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cjo RCSB], [http://www.ebi.ac.uk/pdbsum/6cjo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cjo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CFI1_MEDSA CFI1_MEDSA]] Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.<ref>PMID:10966651</ref> <ref>PMID:11955065</ref> <ref>PMID:11698411</ref>
[https://www.uniprot.org/uniprot/CFI1_MEDSA CFI1_MEDSA] Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.<ref>PMID:10966651</ref> <ref>PMID:11955065</ref> <ref>PMID:11698411</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alfalfa]]
[[Category: Chalcone isomerase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bowman, M E]]
[[Category: Medicago sativa]]
[[Category: Burke, J R]]
[[Category: Bowman ME]]
[[Category: Clair, J J.La]]
[[Category: Burke JR]]
[[Category: Cortina, G]]
[[Category: Cortina G]]
[[Category: Jez, J M]]
[[Category: Jez JM]]
[[Category: Kaltenbach, M]]
[[Category: Kaltenbach M]]
[[Category: Kamerlin, S C.L]]
[[Category: Kamerlin SCL]]
[[Category: Nelson, A T]]
[[Category: La Clair JJ]]
[[Category: Noel, J P]]
[[Category: Nelson AT]]
[[Category: Pabis, A]]
[[Category: Noel JP]]
[[Category: Philippe, R N]]
[[Category: Pabis A]]
[[Category: Tawfik, D S]]
[[Category: Philippe RN]]
[[Category: Woods, K B]]
[[Category: Tawfik DS]]
[[Category: Flavanone]]
[[Category: Woods KB]]
[[Category: Isomerase]]
[[Category: Naringenin]]
[[Category: Plant protein]]

Latest revision as of 17:28, 13 March 2024

Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation.Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation.

Structural highlights

6cjo is a 2 chain structure with sequence from Medicago sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CFI1_MEDSA Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.[1] [2] [3]

References

  1. ↑ Jez JM, Bowman ME, Dixon RA, Noel JP. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nat Struct Biol. 2000 Sep;7(9):786-91. PMID:10966651 doi:10.1038/79025
  2. ↑ Jez JM, Bowman ME, Noel JP. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23;41(16):5168-76. PMID:11955065
  3. ↑ Jez JM, Noel JP. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. J Biol Chem. 2002 Jan 11;277(2):1361-9. Epub 2001 Nov 6. PMID:11698411 doi:10.1074/jbc.M109224200

6cjo, resolution 2.40Å

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