6cjo

Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation.Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation.

Structural highlights

6cjo is a 2 chain structure with sequence from Medicago sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CFI1_MEDSA Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.^[1] ^[2] ^[3]

References

↑ Jez JM, Bowman ME, Dixon RA, Noel JP. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nat Struct Biol. 2000 Sep;7(9):786-91. PMID:10966651 doi:10.1038/79025
↑ Jez JM, Bowman ME, Noel JP. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23;41(16):5168-76. PMID:11955065
↑ Jez JM, Noel JP. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. J Biol Chem. 2002 Jan 11;277(2):1361-9. Epub 2001 Nov 6. PMID:11698411 doi:10.1074/jbc.M109224200

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OCA

[1] Jez JM, Bowman ME, Dixon RA, Noel JP. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nat Struct Biol. 2000 Sep;7(9):786-91. PMID:10966651 doi:10.1038/79025

[2] Jez JM, Bowman ME, Noel JP. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 2002 Apr 23;41(16):5168-76. PMID:11955065

[3] Jez JM, Noel JP. Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences. J Biol Chem. 2002 Jan 11;277(2):1361-9. Epub 2001 Nov 6. PMID:11698411 doi:10.1074/jbc.M109224200

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